Prediction Formulas for Individual Opioid Analgesic Requirements Based on Genetic Polymorphism Analyses

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Prediction Formulas for Individual Opioid Analgesic Requirements Based on Genetic Polymorphism Analyses

BACKGROUND The analgesic efficacy of opioids is well known to vary widely among individuals, and various factors related to individual differences in opioid sensitivity have been identified. However, a prediction model to calculate appropriate opioid analgesic requirements has not yet been established. The present study sought to construct prediction formulas for individual opioid analgesic req...

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One of the most remarkable advances in the past decade has been in unraveling the molecular processes in opioid pharmacology. There have also been substantial advances in our understanding of the mechanisms involved in the processing of nociceptive information. It has become obvious that this is a very complex process, involving multiple neuropeptides, neurotransmitters, and their respective re...

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ژورنال

عنوان ژورنال: PLOS ONE

سال: 2015

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0116885